Emadeldin Hassan E. Konozy Laboratory
Department of Biotechnology
Section : Proteomics and Glycobiology
Full Professor: Biochemistry
Head, Proteomics and Glycobiology Laboratory
Dean, Scientific Research Bureau
Head, Biotechnology Department
Africa City of Technology
4A/2 Blue Nile Bridge Ave, Alamlak, Bahri Central, Khartoum 11111, Sudan.
Tele: +249183799219, FAX: +249183799218.
Phone (Cell): +249 999104999
Plant lectin purification, characterization and their biological activity
The discovery of plant lectins represented a great impulse to current glycobiology researches. Lectins are protein or glycoprotein substances, usually of plant origin. They signify important biochemical components for several applications in the bio-chemical/medical arenas and in research. Sequence determinations and structural characterization assisted to resolve the mechanism of their action in many biological systems and processes. The discovery and characterization of many plant lectins and their specific action on glycan receptors led to explore their possible implementation in arrays of biological and medical applications. For example due to the narrow sugar specificity plant lectins can enter into cells, leading to cancer cells aggregation or agglutination and thereafter inhibit or prevent cancer cells growth. Antiulcer and Antioxidant Activity of many plant lectins have also been documented. Due to their ability to differentiate between normal and malignant cells the potential and the applicability of different plant lectins was investigated to be used as a drug targeting shuttle.
Proteomics of stressed plants
Proteomics is the large-scale study of proteins at their cellular level. Plants usually exposes to various biotic and abiotic types of stresses throughout their life cycle. The abiotic stresses comprise mainly drought, salt, temperature (low/high), flooding and food shortage/excess which hinder plant development and therefore the yield to a great degree.
Knowing the protein expressed by plant to adapt with such stresses will enable to engineer plant with great and improved adaptability to such harsh conditions and therefore enhance their crop yield and economic impact.